Neurogenese | Augenentwicklung | Regionalisierung des Nervensystems | Wegfindung | Opsine und Farbensehen | Chemorezeption | Mechanorezeption | Verhaltensgenetik allgemein | Genetische Kontrolle biologischer Rhytmen  | Lernverhalten
 

Neurogenese

Artavanis-Tsakonas, S., Matsuno, K., Fortini, M.E. (1995): Notch signaling. Science 268: 225-233

Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S., Perrimon, N. (1996): Interaction between wingless and notch signaling pathways mediated by disshevelled. Science 271: 1826-1831

Bhanot, P., Brink, M., Harryman Samos, C., Hsieh, J.-C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J., Nusse, R. (1996): A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature 382: 225-230

Blair, S.S. (1996): Notch and wingless signals collide. Science 271: 1822-1884

Brand A.H. and Perrimon N. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118 (2): 401-415

Campos-Ortega, J. A. (1993): Mechanisms of early neurogenesis in Drosophila melanogaster. J. Neurobiol. 24:1305-1327

Campos-Ortega J.A. and Knust E. (1990). Genetics of early neurogenesis in Drosophila melanogaster. Ann. Rev. Genet. 24: 387-407

Diederich, R.J., Matsuno, K., Hing, H., Artavanis-Tsakonas, S. (1994): Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in Notch signaling pathway. Development 120: 473-481

Doe C.Q., Bastiani M.J. und Goodman C.S. (1986): Guidance of neuronal growth cones in the grasshopper embryo. IV. Temporal delay experiments. J. Neuroscience 6: 3552-3563

Gomez-Skarmeta, J.-L., Diez del Corral, R., de la Calle-Moustienes, E., Ferres-Marco, D., Modolell, J. (1996): Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. Cell 85: 95-105

Goodman C.S. (1979): Isogenic grasshoppers: genetic variability and development of identified neurons. In Neurogenetics: Genetic Approaches to the Nervous System, (ed. X.O. Breakefield), pp.101-151. New York, Oxford: Elsevier.

Hartenstein, A., Rugendorf, A., Tepass, U., Hartenstein, V. (1992): The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 116: 1203-1220

Jan, Y. N., Jan, L.Y. (1993): HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell 75: 827-830

Jimenez, F. and Campos-Ortega, J. A.(1990): Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster. Neuron 5(1): 81-89

Kopan, R., Turner, D.L. (1996): The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr. Opin. Neurobiol. 6: 594-601

Lee, J.E. (1997): Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol. 7: 13-20

Lewis, J. (1996): Neurogenic genes and vertebrate neurogenesis. Curr. Opin. Neurobiol. 6: 3-106

Miller C.A. und Benzer S. (1983): Monoclonal antibody cross-reactions between Drosophila and human brain. PNAS 80: 7641-7645

Ramain, P., Heitzler, P., Haenlin, M., Simpson, P. (1993): Pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc-finger protein with homology to the vertebrate transcription factor GATA-1. Development 119: 1277-1291

Simpson, P. (1996): Drosophila development: A prepattern for sensory organs. Curr. Biol. 6 (8): 948-950

Technau G.M. and Campos-Ortega J. A. (1987): Cell autonomy of expression of neurogenic genes of Drosophila melanogaster. Proc. Natl. Acad. Sci. (USA) 84, 4500-4504

Wehner R. und Gehring W. (1990): Zoologie. Thieme Verlag, Stuttgart, New York.

Augenentwicklung

Baker, N.E., Yu, S. (1997): Proneural function of neurogenic genes in the developing Drosophila eye. Curr. Biol. 7: 122-132

Baker, N.E., Yu, S., Han, D. (1996): Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr. Biol. 6(10): 1290-1301

Basler, K. und Hafen, E. (1988): Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate. Trends Genet 4(3): 74-79 

Bonini, N.M., Choi, K.-W. (1995): Early decisions in Drosophila eye morphogenesis. Curr. Op. Gen. Dev. 5: 507-515

Callaerts, P., Halder, G., Gehring, W.J. (1997): Pax-6 in development and evolution. Ann. Rev. Neurosci. 20: 483-532

Chanut, F., Heberlein, U. (1997): Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina. Development 124: 559-567

Dickson, B. (1995): Nuclear factors in Sevenless signaling. Trends in Genetics 11(3): 106-111

Fischbach, K.-F. und Stuermer, C.A.O. (1989): Weg- und Zielfindung wachsender

Nervenfasern im Sehsystem von Fliegen und Fischen. BiuZ 11: 157-166

Freeman, M. (1996): Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660

Freeman, M. (1997): Cell determination strategies in the Drosophila eye. Development 124: 261-270

Freund, C., Horsford, D.J., McInnes, R.R. (1996): Transcription factor genes and the developing eye: a genetic perspective. Human Molecular Genetics 5: 1471-1488

Graw, J. (1996): Genetic aspects of embryonic eye development in vertebrates. Developmental Genetics 18: 181-197

Halder, G., Callaerts, P., Gehring, W.J. (1995): Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267: 1788-1792

Hassan, B., Vaessin, H. (1996): Regulatory interactions during early neurogenesis in Drosophila. Developmental Genetics 18: 18-27

Heberlein, U., Moses, K. (1995): Mechanisms of Drosophila retinal morphogenesis: the virtues of being progressive. Cell 81: 987-990

Heberlein, U., Singh, C.M., Luk, A.Y., Donohoe, T.J. (1995): Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 373: 709-711

Klämbt, C. (1997): Drosophila development: a receptor for ommatidial recruitment. Curr. Biol. 7: R132-135

Massagué, J., Hata, A., Liu, F. (1997): TGF-b signalling through the Smad pathway. Trends in Cell Biol. 7: 187-192

Mathers, P.H., Grinberg, A., Mahon, K.A., Jamrich, M. (1997): The Rx homeobox gene is essential for vertebrate eye development. Nature 387: 603-607

Penton, A., Selleck, S.B., Hoffmann, F.M. (1997): Regulation of cell cycle synchronisation by decapentaplegic during Drosophila eye development. Science 275: 203-206

Pignoni, F., Zipursky, S.L. (1997): Induction of Drosophila eye development by decapentaplegic. Development 124: 271-278

Reiter, C., Schimansky, T., Nie, Z., Fischbach, K.-F. (1996): Reorganisation of membrane contacts prior to apoptosis in the Drosophila retina: the role of the IrreC-rst protein. Development 122: 1931-1940

Ready D. (1989): A multifaceted approach to neural development. Trends Neuroscience 12: 102-110

Shen, W., Mardon, G. (1997): Ectopic eye development in Drosophila by directed dachshund expression. Development 124: 45-52

Tio, M., Moses, K. (1997): The Drosophila TGFa homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124: 343-351

Wassarman, D.A., Therrien, M., Rubin, G.M. (1995): The Ras signaling pathway in Drosophila. Curr. Op. Gen. Dev. 5: 44-50

Wiersdorf, V., Lecuit, T., Cohen, S.M., Mlodzik, M. (1996): Mad acts downstream of Dpp receptors, revealing a different requirement for Dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122: 2153-2162

Woff, T., Ready, D.F. (1991): Cell death in normal and rough eye mutants of Drosophila. Development 113: 825-839

Wolff, T., Ready, D.F. (1993): Pattern formation in the Drosophila eye. In: The development of Drosophila melanogaster. Cold Spring Harbour Laboratory Press, 1277-1325

Zipursky, L.S., Rubin, G.M. (1994): Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Ann. Rev. Neurosci. 17: 373-397

Regionalisierung des Nervensystems

Arendt, D., Nübler-Jung, K. (1994). Inversion of dorsoventral axis? Nature 371: 26

Chalepakis, G., Stoykova, A., Wijnholds, J., Tremblay, P., Gruss, P. (1993): Pax: gene regulators in the developing nervous system. J. Neurobiology 24: 1367-1384

Cohen, S., Jürgens, G. (1991): Drosophila headlines. Trends Genet. 7(8): 267-272

Finkelstein, R., Boncinelli, E. (1994). From fly head to mammalian forebrain: the story of otd and Otx. Trends Genet. 10(9): 310-315

Finkelstein, R., Perrimon, N. (1991): The molecular genetics of head development in Drosophila melanogaster. Development 112: 899-912

Hirth, F., Therianos, S., Loop, T., Gehring, W. J., Reichert, H., Furukubo-Tokunaga, K. (1995): Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila. Neuron 15: 769-778

Joyner, A. L. (1996): Engrailed, Wnt, and Pax genes regulate midbrain-hindbrain development. Trends Genet. 12(1): 15-20

Redies, C., Takeichi, M. (1996): Cadherins in the developing central nervous system: an adhesive code for segmental and functional subdivisions. Dev. Biol. 180: 413-423

Rubenstein, J.L.R., Puelles, L. (1994): Homeobox gene expression during development of the vertebrate brain. Curr. Topics Dev. Biol. 29: 1-65

Schmitt-Ott, U., Technau, G. M. (1992): Expression of en and wg in the embryonic head and brain of Drosophila indicates a refolded band of seven segment remnants. Development 116(1): 111-125

Schmitt-Ott, U., Gonzalez-Gaitan, M., Jäckle, H., Technau, G.M. (1994): Number, identity, and sequence of the Drosophila head segments as revealed by neural elements and their deletion patterns in mutants. Proc. Natl. Acad. Sci. USA. 91: 8363-8367

Thor, S. (1995): The genetics of brain development: conserved programs in flies and mice. Neuron 15: 975-977

Walldorf U., Gehring, W. J. (1992): Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development. EMBO J. 11(6): 2247-2259

Younossi-Hartenstein, A., Green, P., Liaw, G. J., Rudolph, K., Lengyel, J., Hartenstein, V. (1997): Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd. Dev. Biol. 182: 270-283

Wegfindung

Caroni, P., Schwab, M.E. (1988): Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1: 297-326

Cremer, H., Lange, R., Christoph, A., Plomann, M., Vopper, G. et al. (1994): Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367: 455-459

Dechant, G., Barde, Y.-A. (1997): Signalling through the neurotrophin receptor p75NTR. Curr. Opinion in Neurobiol. 7: 413-418

Dörries, U., Taylor, J., Xiao, Z., Lochter, A., Montag, D., Schachner, M. (1996): Distinct effects of recombinant tenascin-C domains on neuronal cell adhesion, growth cone guidance and neuronal polarity. J. Neuroscience Research 43: 420-438

Elkins, T., Zinn, K., McAllister, L., Hoffmann, F.M., Goodman, C.S. (1990): Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell 60(4): 565-575 

Erickson, H.P. (1993): Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Current Opinion in Cell Biology 5: 869-876

Fambrough, D., Goodman, C.S. (1996): The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Cell 87: 1049-1058

Fischbach, K.-F., Stuermer, C.A.O. (1989): Weg- und Zielfindung wachsender Nervenfasern. Biologie in unserer Zeit 19: 157-166

Fischbach, K.-F. und Dittrich, A.P.M. (1989): The optic lobe of Drosophila melanogaster. Part I: A golgi analysis of wild-type structure. Cell Tissue Res. 258: 441-475

Fischbach, K.-F., Barleben, F., Boschert, U., Dittrich, A.P.M., Gschwander, B., Hoube, B., Jäger, R., Kaltenbach, E., Ramos, R.G.P., and Schlosser, G. (1989): Developmental studies on the optic lobe of Drosophila melanogaster using structural brain mutants. In: Neurobiology of Sensory Systems. pp 171-194 Eds. R. N. Singh and N. J. Strausfeld. Plenum Press

Goodman, C. (1996): Mechanisms and molecules that control growth cone guidance. Ann. Rev. Neurosci. 19: 341-377

Gundersen, R.W., und Barrett J.N. (1979): Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor. Science 206(4422): 1079-1080

Harpaz, Y., Chothia, C. (1994): Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J. Mol. Biol. 238: 528-539

Kapfhammer, J.P., Raper, J.A. (1987): Collapse of growth cone structure on contact with specific neurites in culture. J. Neurosci. 7: 201-212

Kim, Y.T. and Wu, C.F. (1987) Reversible blockage of neurite development and growth cone formation in neuronal cultures of a temperature-sensitive mutant of Drosophila. J Neurosci 7(10): 3245-3255 

Krull, C.E., Oland, L.A., Faissner, A., Schachner, M., Tolbert, L.P. (1994): In vitro analysis of neurite outgrowth indicates a potential role for tenascin-like molecules in the development of insect olfactory glomeruli. J. Neurobiology 25: 989-1004

Letourneau, P.C. (1975): Cell-to-substratum adhesion and guidance of axonal elongation. Dev. Biol. 44(1): 92-101

Luo, Y, Shepherd, I., Li, J., Renzi, M.J., Chang, S., Raper, J.A. (1995): A family of molecules related to collapsin in the embryonic chick nervous system. Neuron 14: 1131-1140

Mayford, M., Barzilai, A., Keller, F., Schacher, S., Kandel, E.R. (1992): Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science 256: 638-644

Ramon y Cajal, S. (1893): La retine des vertebres. La Cellule 9: 119-258

Rechsteiner, M. (1990): PEST sequences are signals for rapid intracellular proteolysis. Seminars in Cell Biology 1: 433-440

Rutishauser, U. (1991): Pleiotropic biological effects of the neural cell adhesion molecule NCAM. Seminar Neurosciences 3: 265-270

Schwab, M.E., Kapfhammer, J.P., Bandtlow, C.E. (1993): Inhibitors of neurite growth. Ann. Rev. Neurosci. 16: 565-595

Sperry, R.W. (1963): Chemoaffinity in the orderly growth of nerve fiber patterns and connections. PNAS (USA) 50: 703-710

Tessier-Lavigne, M., Goodman, C.S. (1996): The molecular biology of axon guidance. Science 274: 1123-1133

Tessier-Lavigne, M., Placzek, M., Lumsden, A.G., Dodd, J., Jessell, T.M. (1988): Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 336: 775-778

Vielmetter, J., Stuermer C.A.O. (1989): Goldfish retinal axons respond to position-specific properties of tectal cell membranes in vitro. Neuron 2: 1331-1339

Walter, J., Henke-Fahle, S., Bonhoeffer, F. (1987): Avoidance of posterior tectal membranes by temporal retinal axons. Development 101: 909-913

Williams, E.J., Furness ,J. Walsh ,F.S., Doherty, P. (1994): Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 13: 583-594

Opsine und Farbensehen

Chang, B.S., Crandall, K.A., Carulli, J.P., Hartl, D.L. (1995): Opsin phylogeny and evolution: a model for blue shifts in wavelength regulation. Mol. Phylogenet. Evol. 4(1): 31-43 

Nathans, J., Piantanida, T.P., Eddy, R. L., Shows, T.B., Hogness, D. (1986): Molecular genetics of inherited variation in color vision. Science 232: 203-210

Nei, M, Zhang, J, Yokoyama, S. (1997): Color vision of ancestral organisms of higher primates. Mol. Biol. Evol. 14(6): 611-618 

Yokoyama ,S. (1996): Molecular evolution of retinal and nonretinal opsins. Genes Cells 1(9): 787-794 

Chemorezeption

Buck, L, Axel, R. (1991): A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65: 175-187

Carlson, J. R. (1996): Olfaction in Drosophila: From odor to behavior. Trends in Genetics 12 (5): 175-180

Chess, A., Simon, I., Cedar, H., Axel, R. (1994): Allelic inactivation regulates olfactory receptor gene expression. Cell 78: 823-834

Dulac, C., Axel, R. (1995): A novel family of genes encoding putative pheromone receptors in mammals. Cell 83: 195-206

Griff, I., Reed, R.R. (1995): The genetic basis for specific anosmia to isovaleric acid in the mouse. Cell 83: 407-414

Margolskee, R.F. (1993): The molecular biology of taste transduction. BioEssays 15: 645-650

Sengupta, P., Chou, J.H., Bargmann, C. (1996): odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell 84: 899-909

Troemel, E.R., Chou, J.H., Dwyer, N.D., Colert, H., Bargmann, C. (1995): Divergent seven transmembrane receptors are candidate chemosensory receptors. Cell 83: 207-218

Mechanorezeption

Garcia-Anoveros, J., Corey, D.P. (1996): Touch at the molecular level. Curr. Biol. 6 (5): 541-543

Huang, M., Chalfie, M. (1994): Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature 367: 467-470

Bargmann, I.C. (1994): Molecular mechanisms of mechanosensation. Cell 78: 729-731

Hong, K., Driscoll, M. (1994): A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature 367(6462): 470-473

Verhaltensgenetik allgemein

Amrein, H., Axel, R. (1997): Genes expressed in neurons of adult male Drosophila. Cell 88: 459-469 

Bailey, J. M. (1995): Sexual orientation revolution. Nature Genetics 11: 353-354

Barinaga, M. (1995): Bisexual fruit flies point to brain courtship centers. Science 267: 791-792

Benjamin, J., Li, L., Patterson, C., Greenberg, B.D., Murphy, D.L., Hamer, D.H. (1996): Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nature Genetics 12: 81-84

Brown, J.R., Ye, H., Bronson, R.T., Dikkes, P., Greenberg, M.E. (1996): A defect in nurturing in mice lacking the immediate early gene fosB. Cell 86: 297-309

Ebstein, R.P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E.R., Nemanov, L., Katz, M., Belmaker, R.H. (1996): Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nature Genetics 12: 78-80

Eley, T.C., Plomin, R. (1997): Genetic analyses of emotionality. Curr. Opin. Neurobiology 7: 279-284

Ferveur, J.-F., Stöhrtkuhl, K.F., Stocker, R.F., Greenspan, R.J. (1995): Genetic feminization of brain structures and changed sexual orientation in male Drosophila. Science 267: 902-905

Finkelstein, R., Boncinelli, E. (1994): From fly head to mammalian forebrain: the story of otd and Otx. Trends in Genetics 10(9): 310-315

Finlay, K. D., Taylor, B. J., Milstein, M., McKeown, M. (1997): dissatisfaction, a gene involved in sex-specific behaviour and neural development of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 94: 913-918

Flint, J., Corley, R., DeFries, J.C., Fulkner, D.W., Gray, J.A., Miller, S., Collins, A.C. (1995): A simple genetic basis for a complex psychological trait in laboratory mice. Science 269: 1432-1435

Greenspan, R. J. (1995): Understanding the genetic construction of behaviour. Sci. Amer. 272(4): 74-79

Hall, J.C. (1979): Control of male reproductive behaviour by the central nervous system in Drosophila: dissection of a courtship pathway by genetic mosaics. Genetics 92: 437-457

Hall, J.C. (1994): The mating of a fly. Science 264:1702-1714

Hamer, D.H., Hu, S., Magnuson, V.L., Hu, N.A., Pattatucci, M.L. (1993): A linkage between DNA markers on the X chromosome and male sexual orientation. Science 261: 321-327

Hu, S.A., Pattatucci, M.L., Patterson, C., Li, L., Fulker, D.W., Cherny, S.S., Kruglyak, L., Hamer, D.H. (1995): Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nature Genetics 11: 248-251

Ito, H. Fuitani, K., Usui, K., Shimizu-Nishikawa, K., Tanaka, S., Yamamoto, D.(1996): Sexual orientation in Drosophila is altered by the sartori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain. Proc. Natl. Acad. Sci. U.S.A. 93: 9687-9692

King, M.-C. (1993): Sexual orientation and the X. Nature 364: 288-289

Lesch, K.-P., Begel, D., Heis, A., Sabo, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Müller, C.R., Hamer, D.H., Murphy, D.L. (1996): Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527-1531

Maddox, J. (1993): Wilful public misunderstanding of genetics. Nature 364:281 

O'Dell, K.M.C., Kaiser, K. (1997): Secrets and flies. Curr. Biol. 7: R345-R347

Plomin, R., DeFries, J.C., McClearn, G.E., Rutter, M. (1997): Behavioral genetics. (3. ed.), W.H. Freeman, New York

Plomin, R., Owen, M.J., McGuffin, P. (1994): The genetic basis of complex human behaviors. Science 264: 1733-1739

Ryner, L.C., Goodwin, S.F., Castrillon, D.H., Anand, A., Vilella, A., Baker, B.S., Hall, J.C., Taylor, B.J., Wasserman, S.A. (1996): Control of male sexual behaviour and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-1089

Genetische Kontrolle biologischer Rhythmen

Antoch, MP., Song, E.J., Chang, A.M., Vitaterna, M.H., Zhao, Y., Wilsbacher, L.D., Songoram, A.M., King, D.P., Pinto, L.H.P., Takahashi, J.S. (1997): Functional identification of the mouse circadian clock gene by transgenic BAC rescue. Cell 89: 655-667

Aronson, B.D., Johnson, K.A., Loros, J.J., Dunlap, J.C. (1994): Negative feedback defines a circadian clock: autoregulation of the clock gene frequency. Science 263: 1578-1584

Aschoff J. (1958): Tierische Periodik unter dem Einfluß von Zeitgebern. Z. Tierpsychologie 15: 1-30

Bünning E. (1977). Die physiologische Uhr. 3. Auflage. Springer Verlag, Berlin, Heidelberg, New York.

Colot, H.V., Hall, J.C., Rosbash ,M. (1988): Interspecific comparison of the period gene of Drosophila reveals large blocks of non-conserved coding. EMBO J. 7: 3929-3937

Crosthwaite, S.K., Loros, J.J., Dunlap, J.C. (1995): Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript. Cell 81:1003-1012

Curtin, K.D., Huang, Z. J., Rosbash, M. (1995): Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron 14: 365-372 

Edery, I., Rutila, J.E., Rosbash, M. (1994): Phase shifting of the circadian clock by induction of the Drosophila period protein. Science 263: 237-240

Ewer, J., Frisch, B., Hamblen-Coyle, M.J., Rosbash, M., Hall, J.C. (1992): Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells influence on circadian behavioral rhythms. J. Neurosci.12: 3321-3349

Garceau, N.Y., Liu, Y., Loros, J.J., Dunlap, J.C. (1997): Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein Frequency. Cell 89: 469-476

Gekakis, N., Saez, L, Delahaye-Brown, A.M., Myers, M.P., Sehgal, A., Young, M.W., Weitz, C.J. (1995): Isolation of timeless by Per protein interaction: defective interaction between timeless. Science 270(5237): 811-815

Hall, J.C. (1981): Sex behavior mutants in Drosophila. Bioscience 31: 125-130

Hall, J. C. (1985): Neural and developmental implications of the genetic and molecular analysis of behavior. In: Edelman,G.M., Gall, W.E., Cowan, W.M.. (eds.) Molecular bases of neural development; Annual Symposia of the Neurosciences Institute of the Neurosciences Research Program. John Wiley & Sons New York , p. 565-587

Helfrich-Förster, C. (1995): The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 92: 612-616 

Helfrich-Förster, C. (1996): Drosophila rhythms: from brain to behavior. Sem. Cell & Developmental Biol. 7: 791-802 

Hunter-Ensor, M., Ousley, A., Sehgal, A. (1996): Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84: 677-685

Iwasaki, K., Thomas, J.H.,(1997): Genetics in rhythm. Trends in Genetics 13: 111-115

King, D. P., Zhao, Y., Sangora, A.M., Wilsbacher, L.D., Tanaka, M., Antoch, M., Steeves, D.L., Vitaterna, M.H., Kornhauser, J.M., Lowrey, P.L., Turek, F.W., Takahashi, J.S. (1997): Positional cloning of the mouse circadian clock gene. Cell 89: 641-653 

Kondo, T., Tsinoremas, N.F., Golden, S.S., Johnson, C.H., Kutsuna, S., Isjiura, M. (1994): Circadian clock mutants of Cyanobacteria. Science 266: 1233-1236

Konopka, R.J., Benzer, S. (1971): Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 68: 2112-2116

Kyriacou, C.P., Hall, J.C. (1980): Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc. Natl .Acad .Sci .U.S.A. 77: 6729-6733 

Lee, C., Parikh, V., Itsukaichi, T., Bae, K., Edery, I. (1996): Resetting the Drosophila clock by photic regulation of Per and a Per-Tim complex. Science 271: 1740-1744

Myers, M.P., Wager-Smith, K., Wesley, C.S., Young, M.W., Sehgal, A. (1995): Positional cloning and sequence analysis of the Drosophila clock gene, timeless. Science 270: 805-808

Myers, M.P., Wager-Smith, K., Rothenfluh-Hilfiker, A., Young, M.W. (1996): Light-induced degradation of Timeless and entrainment of the Drosophila circadian clock. Science 271: 1736-1740

Reppert, S.M., Sauman, I. (1995): Period and timeless tango: a dance of two clock genes. Neuron 15: 983-986 

Reppert, S.M., Weaver, D.R. (1997): Forward genetic approach strikes gold: cloning of a mammalian clock gene. Cell 89: 487-490 

Rosato, E., Peixoto, A.A., Gallippi, A., Kyriacou, C.P., Costa, R. (1996): Mutational mechanisms, phylogeny, and evolution of a repetitive region within a clock gene of Drosophila melanogaster. J. Mol. Evol. 42(4): 392-408 

Rosbash, M. (1995): Molecular control of circadian rhythms. Curr. Opin. Genet. Dev. 5: 662-668 

Sehgal, A., Price, J.L., Man, B., Young, M.W. (1994): Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263: 1603-1606

Takahashi, J. S. (1995): Molecular neurobiology and genetics of circadian rhythms in mammals. Ann. Rev. Neurosci. 18: 531-553

Tosini, G., Menaker, M. (1996): Circadian rhythms in cultured mammalian retinae. Science 272: 419-421

Vitaterna, M.H., King, D.P., Chang, A.-M., Kornhauser, J.M., Lowrey, P.L., McDonald, J.D., Dove, W.F., Pinto, L.H., Turek, F.W., Takahashi, J.S. (1994): Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719-725

Vosshall, L.B., Price, J.L., Sehgal, A., Saez, L., Young ,M.W. (1994): Specific block in nuclear localization of period protein by a second clock mutation, timeless. Science 263: 1606-1609

Welsh, D.K., Logothetis, D.E., Meister, M., Reppert. S.M. (1995): Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 14: 697-706

Wheeler, D.A., Kyriacou, C.P., Greenacre, M.L., Yu, Q., Rutila, J.E., Rosbash, M., Hall, J.C. (1991): Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science 251: 1082-1085 

Zeng, H., Hardin, P.E., Rosbash, M. (1994): Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J. 13: 3590-3598

Lernverhalten

Abel, T., Nguyen, P.V., Barad, M., Deuel, T.A.S., Kandel, E.R. und Bourtchouladze ,R. (1997): Genetic demonstration of a role for PKA in the late phase of LTP and in Hippocampus-based long-term memory. Cell 88: 615-26

Davis, G.W., Schuster, C.M., Goodman, C.S. (1996): Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 17: 669-679

Erber J., Masuhr T., und Menzel R. (1980): Localization of short-term memory in the brain of the bee, Apis mellifera. Physiol. Entomol. 5: 343-358

Frank, D.A., Greenberg, M.E. (1994): CREB: a mediator of long-term memory from molluscs to mammals. Cell 79: 5-8

Goodman, C.S., Shatz, C.J. (1993):. Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell 72Suppl: 77-98

Hawkins, R.D., Kandel, E.R., Siegelbaum, S.A. (1993): Learning to modulate transmitter release. Ann. Rev. Neurosci. 16: 625-65

Hebb, D.O. (1949). The organization of behaviour. Wiley, N.Y.

Hedge, A.N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D.G., Martin, K.C., Kandel, E.R., Schwartz, J.H. (1997): Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89: 115-126

Heisenberg, M., Borst, A., Wagner, S., Byers, D. (1985): Drosophila mushroom body mutants are deficient in olfactory learning. J. Neurogenet. 2: 1-30

Kandel E.R. (1981): Behavioral Biology of Aplysia. W.H. Freeman and Company, San Francisco

Kandel E.R. und Hawkins R.D. (1992): The biological basis of learning and individuality. Sci. Am. 267: 78-86

Kornhauser, J.M., Greenberg, M.E. (1997): A kinase to remember: dual roles for MAP Kinase in long-term memory. Neuron 18: 839-842

Martin, K.C., Kandel, E.R. (1996): Cell adhesion molecules, CREB, and the formation of new synaptic connections. Neuron 17: 567-570

Roush, W. (1996): The supple synapse: an affair that remembers. Science 274: 1102-1104

Schuster, C.M., Davis, G.W., Fetter, R.D., Goodman, C.S. (1996): Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17: 641-654

Schuster, C.M., Davis, G.W., Fetter, R.D., Goodman, C.S. (1996): Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron 17: 655-667

Shatz C.J. (1990): Impulse activity and the patterning of connections during CNS development. Neuron 5: 1-10

Yin, J.C.P., Tully, T. (1996): CREB and the formation of long-term memory. Curr. Op. Neurobiol. 6: 264-268